Faculty of Biological Sciences
Institute of Molecular & Cellular Biology
Astbury Centre for Structural Molecular Biology
University of Leeds UK
Research Fellow
(Fixed term for 3 years, available from 1 December 2008)
Project Title: Structure and Mechanism of Cytoplasmic Dynein
You will be based in Dr Stan Burgess’ lab working on cryo-electron
microscopy of cytoplasmic dynein motor protein in complex with
microtubules, funded by Human Frontiers Science Program. This
project is in collaboration with Prof. H. Higuchi and Dr. T. Kon
(University of Tokyo) and Dr. A. Vilfan (J. Stefan Institute,
Slovenia). Experience of cryo-electron microscopy and three-
dimensional image processing of single particles is highly
desirable. Cryo-microscopy will be performed using a Technai F20
microscope fitted with a 4k CCD camera. Cryo-electron tomography
will also be available for this project. Some negative stain work
will also be used for initial characterization. Image processing
will be performed using SPIDER, Imagic and EMAN on a 150-processor
Linux cluster and numerous graphics workstations. A PhD in
structural biology, electron microscopy, biochemistry, image
processing or a related area, and experience with and the ability to
use technically sophisticated equipment are essential.
University Grade 6 (£24,152 - £28,839 p.a.) or Grade 7 (£29,704 -
£35,469 p.a.)
Informal enquiries to Dr. Stan Burgess, tel +44 (0)113 343 4170,
email [EMAIL PROTECTED]
To download an application form and job details please visit
www.leeds.ac.uk and click on jobs. Alternatively these may be
obtained from Mr A Bateman, Faculty Staff Recruitment Office, tel +44
(0)113 343 8040, email [EMAIL PROTECTED]
Job ref 316131. Closing date Wednesday 19th November 2008 (10am).
________________________
Dr Stan Burgess
Lecturer in Molecular Contractility
Astbury Centre for Structural Molecular Biology,
Institute of Molecular and Cellular Biology,
University of Leeds,
Leeds,
LS2 9JT
UK
tel +44 113 343 4170
Room 6.01 Miall
Visit us at:
http://www.dynein.org
http://www.contractility.org
________________________
