Many people responded with questions following our first announcement of a ready-to-use small fragment screening library designed for protein crystallographic screening. Given suitable crystals, the methodology is of interest to anyone wishing to probe ligand binding interactions and motifs in accessible sites on the protein.
A document describing the library design philosophy, chemical property parameters, practical application in protein crystallography and provision of structure data is available from Leslie Hernandez (les...@zenobiatherapeutics.com). A SD file showing the chemical structures of compounds in the library (352 ring-containing compounds with mean MW 154Da) is also available on request. Zenobia Therapeutics http://www.zenobiatherapeutics.com/
