Re: [ccp4bb] Rosettadock/Robetta server Interface analysis

[Anastassis Perrakis]

On 9 Jul 2009, at 19:16, Josiah Obiero wrote:

Hi all,

I am trying to compare the binding affinities of two small proteins to a bigger receptor protein by interface analyis (computational interface alanine scanning by Rosettadock/Robetta server). I was wondering:

1. If it possible to use DDGs of the individual amino acid residues to predict binding affinities

2. If there is another method of predicting binding affinities in silico

FoldX does a good job for me.

Tassos

Thanks,

Regards,

Josiah.