Hi everyone, I am trying to use density modification at rather low resolution (4-5A ) for an RNA structure. My first time ever with RNA. I usually use Histogram matching as part of the density modification scheme in DM. But this method is based on density distribution of protein maps I think. Is histogram matching still valid when it comes to RNA or protein/RNA structures ?
And a general question regarding density modification and RNA structure. Can statistical density modification programs (RESOLVE, Pirate) take into consideration the chemical composition of the structure ? Shouldn't this composition affect the expected density distributions ? My gratitude in advance for your comments and advice, Peter.
