Post Doctoral Training Fellow - David Barford's team - Section of Structural Biology - Institute of Cancer Research - London
Applications are invited for a post-doctoral training fellow to join a team investigating the structure and mechanism of proteins that regulate the cell cycle and signal transduction processes implicated in cancer. The aim of this project is to apply X-ray crystallographic techniques to determine the structure and mechanism of RAS converting enzyme (RCE1), a novel intramembrane protease responsible for post-translational processing of the C-terminal CAAX motif of RAS and a range of other signalling proteins. This work will provide a framework for initiating high-throughput structure-based inhibitor design to develop novel anti-cancer therapies targeted at RAS signalling pathways. Based within Prof. David Barford’s group the project involves a combination of biochemical, structural and inhibitor design approaches. The project would suit a highly motivated and committed scientist interested in molecular mechanisms of signal transduction and cancer biology, membrane proteins and drug discovery. The successful applicant will hold a PhD in X-ray crystallography and have experience with molecular biology, protein expression, purification and crystallisation, preferably of membrane proteins. The position is offered on a fixed term contract available from Jan 2010 up to 30th Sep 2012 in the first instance with a starting salary in the range £29,695 to £34,353 p.a. according to experience. Informal enquires may be made to D. Barford (Tel:+44(0)20 7153 5420 / Email: david.barf...@icr.ac.uk). http://www.icr.ac.uk/research/research_profiles/2958.shtml Please Note - this email address is for enquiries only; CVs must be submitted in line with the instructions below. To apply, please send two copies of your CV and covering letter addressing where you meet the person specification (incl. the names and addresses of two referees) together with a completed Equal Opportunities Monitoring Form to the HR Office, The Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP quoting job Ref C259. Closing date for applications: 2 October 2009 http://www.icr.ac.uk/jobs/current_vacancies/13649.shtml The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network.
