I would normally do the second, unless they are pretty clearly nonisomorphous. If you combine them in Pointless, this will reset the batch numbers automatically.
Phil On 2 Jul 2010, at 05:35, Fengyun Ni wrote: > Hi all, > > I have a question on how to combine two dataset from different crystal of > the same > protein. > > The first way I could think of is that, > 1) Merge two dataset seperately; > 2) Scale them to see whether they are consistent with each other enough as > indicated by > the R-factor; > 3) If the R is low enough, say below 10 or 15%, then take the average for > both the F and > SIGF. > > The other way is that, > 1) Take the unmerged file from MOSFLM, and reset their batch number; > 2) Run SCALA to scale these two unmerged dataset at the same time. > > Could anyone tell which way is the better or the correct way? > Thank you in advance! > > -- > alphar
