A POSTDOCTORAL POSITION to study naturally occurring and rationally
designed PHOTORECEPTORS is available at the Department of Biomolecular
Mechanisms at the Max Planck Institute for Medical Research, Heidelberg.
The highly interdisciplinary group focuses on understanding reaction
mechanisms using crystallographic analysis of reaction intermediates
with a strong emphasis in physical biochemistry. Detailed information
can be found at: http://wbmm.mpimf-heidelberg.mpg.de
Photoreceptors are light sensitive switches that exist in ON and OFF
states that (in)activate associated effectors via a structural change.
Like for every mechanical device, knowledge of its architecture and the
changes occurring during function helps to understand and to rationally
modify the switch. We are studying blue light-regulated
phosphodiesterases, cyclases and transcription factors biochemically and
structurally by X-ray crystallography and time-resolved SAXS/WAXS. For
future applications of these systems in cellular or neurobiological
applications (optogenetics) we are also rationally designing switches.
(See for example Barends et al., Nature, 459: 1015-1018 , Wu et al.,
Nature 461:104-108).
The projects are at various experimental stages, so that the successful
candidate can start productive work immediately.
We are looking for highly motivated candidate with a strong background
in X-ray crystallography and/or SAXS/WAXS who can interact
collaboratively among a variety of disciplines. The successful candidate
should have at least one first-author publication describing a de-novo
structure determination. We offer a highly stimulating interdisciplinary
and international research environment, excellent working conditions and
facilities, including regular access to the Swiss Light Source. The
position is initially for two years, but has longer term perspective,
given excellent performance. There are possibilities to join other
ongoing exciting structural projects of high scientific impact.
To apply, please send a CV including a brief description of your
research/scientific interests, a list of publications, a copy of the
most relevant publication, and names and email addresses of two referees
either as email attachments to
bmm.recruitm...@mpimf-heidelberg.mpg.de, indicating the keyword
photoreceptor.
Informal enquiries may be sent to
Ilme Schlichting (ilme.schlicht...@mpimf-heidelberg.mgp.de)
Deadline for applications is February 15th, 2011, desired starting date
is as soon as possible.
