Structural Biology Positions Pfizer Research and Development
La Jolla, California Pfizer Worldwide Research and Development La Jolla, have two open positions for talented and creative structural biology research scientists in the Structural Biology Group, Department of Cancer Research Chemistry. The successful candidates will have significant experience in all modern sub-disciplines of structural biology and their applications to structure based drug design and protein science aspects of drug discovery projects. We are particularly interested in candidates who have demonstrated an ability to apply innovative and high quality research to answer challenging and unprecedented structural biology and protein science questions and who desire to apply these abilities to challenging targets in the oncology therapeutic area. Experience in signal transduction structural biology and biochemistry would be an advantage. The positions will be filled at the level of Senior Scientist or Principal Scientist. Position 1 will primarily focus on the following areas: 1) generation and utilization of protein structural models to guide construct design for protein expression, crystallization and to refinement of SBDD platforms. 2) protein and protein-small molecule complex crystallization. 3) biophysical characterization of proteins and protein-ligand complexes (including but not limited to- ITC, SPR, and AUC) to facilitate protein crystallization and protein science studies. Additional areas which Position 1 may support as needed include; protein purification, x-ray data collection (synchrotron and in-house), x-ray data processing, structure determination (precedented and novel) and interpretation. Position 2 will primarily focus on the following areas: 1) generation and utilization of protein structural models to guide construct design for protein expression, crystallization and refinement of SBDD platforms. 2) protein and protein-small molecule complex crystallization. 3) x-ray data collection (synchrotron and in-house) including SAXS, x-ray data processing, structure determination (precedented and novel) and interpretation. Additional areas which Position 2 may support as needed include; protein purification, biophysical characterization of proteins and protein-ligand complexes (including but not limited to- ITC, SPR, and AUC) to facilitate protein crystallization and protein science studies. Candidates will also possess the following skills: Excellent oral and written communication skills and good presentation skills. Excellent interpersonal skills which facilitate knowledge sharing and scientific discussions. Ability to quickly and effectively operate, communicate and influence decision making within cross-functional and multi-disciplinary teams comprising; biochemists, biologists, chemists, crystallization scientists, protein scientists and x-ray crystallographers. Applicants will have the minimum requirements of a PhD and Postdoctoral experience in Structural Biology, Biochemistry or a closely related field. 3-5 years of drug discovery experience in Biotechnology or Pharmaceutical sectors would be an advantage. For further information or to submit your curriculum vitae for consideration contact: Al Stewart Ph.D. Director of Structural Biology Department of Cancer Research Chemistry Pfizer Research La Jolla, California 92121 al.e.stew...@pfizer.com Tel: +1 858 622 3139
