Re: [ccp4bb] Soaking Kinase Crystals with ATP analogues

[Yuri Pompeu]

Maybe someone has suggested this already... If so, I am re-enforcing it. 
If the cracking is coming from actual molecular movement induced by binding 
(and not other reason like differing ionic strength in your soaking conditions) 
you could try setting up some co-crystallization and (hopefully)
grow some enzyme-substrate complex crystals...
hth
yuri