A postdoctoral position at Yale University School of Medicine is available immediately for highly motivated, creative individuals with a strong interest in the structure, function, and pharmacology of signaling proteins implicated in neurological and neuropsychiatric diseases. We are presently focusing our efforts on central nervous system transporters using a combination of steady-state kinetics, radioligand binding, X-ray crystallography, and other complementary biochemical/biophysical techniques.
The laboratory is located in newly-renovated space in the Department of Cellular and Molecular Physiology in a highly collaborative environment. We have state of the art tissue culture facilities, purification equipment, and LINUX workstations. We have regular access to Mosquito and Art Robbins Gryphon LCP (lipidic cubic phase) crystallization robots, Formulatrix imager with UV detection, in-house X-ray diffractometer, synchrotron beamlines, and number of biophysical instruments. These include a CD spectrometer, analytical ultracentrifuge, differential scanning calorimeter, isothermal titration calorimeter, surface plasmon resonance, static/dynamic light scattering, and stopped flow fluorometer. Candidates must hold (or soon expect to hold) a Ph.D. in biochemistry, biophysics, or a related field and have a strong publication record. Experience in recombinant DNA methods, protein expression and purification, and X-ray crystallography is required. Prior work with membrane proteins, insect/mammalian expression systems, and functional assays is preferred. The candidate must have an excellent command of oral and written English. He/she must be capable of working independently but also be willing to work as part of a team. For more information, please contact me via e-mail. Applicants should send a CV, along with a summary of previous research experience and interests, and arrange to have 3 reference letters sent to Satinder K. Singh via e-mail at satinder.k.si...@yale.edu Additional contact information is given below: Satinder K. Singh, Ph.D. Assistant Professor of Cellular and Molecular Physiology Yale University School of Medicine 333 Cedar Street, SHM B147 Lab room # SHM BE11/17 P.O. Box 208026 New Haven, CT 06520-8026 Office #: 203-737-4861 Fax #: 203-785-4951 E-mail: satinder.k.si...@yale.edu Website: http://physiology.yale.edu/people/satinder_k_singh-3.profile
