We seek to appoint a post-doctoral training fellow to the Division of Structural Biology in the new team led by Dr Alessandro Vannini to undertake crystallographic, single particle electron microscopy analysis and biochemical analysis of large macromolecular complexes that assemble at RNA Polymerase III loci across the eukaryotic genome, in order to mechanistically understand their role in cancer and other fundamental cellular processes (www.icr.ac.uk/alessandrovannini).
The Division of Structural Biology has managed facilities for protein crystallography (Bruker Microstar and CCD detector and crystallisation robots), cryo-electron microscopy (FEI Tecnai F20 and T12), and protein production with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60 L fermentor). The Division is also well equipped with equipment for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Applicants should possess a PhD (or equivalent) in biochemistry or molecular biology with a sound knowledge of protein crystallography an/or single particle electron microscopy. Experience in the biochemical and biophysical characterization of multi-subunit and protein-nuclei acids complexes is highly desirable. Experience in protein production in insect cells (MultiBac) or yeast genetics would be an advantage. Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary in the range of £27,536 to £33,852 p.a. inclusive (based on previous post-doctoral experience). For further particulars and details of how to apply, please check the current vacancies in the division of Structural Biology on our online application website (https://www.icr.ac.uk/jobs/index.shtml) and refer to this vacancy (n. 1228522). Closing date: 16th May 2012 Please direct informal inquiries to Dr. Alessandro Vannini at alessandro.vann...@icr.ac.uk
