Search for homologous binding partners with close or remote homologies with your own sequences can also be addressed from the InterEvol database http://biodev.cea.fr/interevol/ It seems you can upload the sequences there : http://biodev.cea.fr/interevol/interevalign.aspx
Hope this can help Marie-Ln Dr Marie-Hélène LeDu Laboratoire de Biologie Structurale et Radiobiologie CEA/DSV/IBiTec-S, CEA Saclay Bât 144, pièce 25 91191 Gif-sur-Yvette, France Tel : 33 (0)1 69 08 71 35 E-mail : marie-helene.l...@cea.fr Le 06/09/12 14:20, « moham...@strubi.ox.ac.uk » <moham...@strubi.ox.ac.uk> a écrit : >Hi Careina, > >In answer to your first question you could also try the iPATCH server: > >http://portal.stats.ox.ac.uk/userdata/proteins/i-Patch/home.pl > >This takes two reference structures for proteins that interact, and >combined with multiple sequence alignments of their homologs attempts to >predict the surface contact residues between them. > >As far as your second question is concerned, a quick google search using >the term "protein interaction prediction from sequence" gave some useful >links, one of which is Struct2Net: > >http://groups.csail.mit.edu/cb/struct2net/webserver/ > >This tool attempts to predict protein-protein interactions purely from >sequence data. However, it does use a structure-based threading approach, >so your sequences will be run against the pdb. If they are unique to >anything in the structural databases, it may not be useful. > > >Hope this helps, > >Mohammad > > >---------------------------------------- >Dr. Mohammad W. Bahar >Division of Structural Biology >Wellcome Trust Centre for Human Genetics >University of Oxford
