Hi all, I'm having great trouble building/refining a structure which has several regions of obvious flexibility/disorder... Regions where the density is fragmented and I have no clear way of building the chain (at least with any confidence). The protein is dimeric with some variation in the extent of those regions which are not interpretable, and simply copying from the ncs mate does not work! So the question is how far can one refine such a structure - is there a measure of 'completion''? I recall that there is, but I must be getting old. Am I miss-remembering?
Cheers in advance Dean
