My work with colicin M class bacteriocins shows that they require Ca2+ (or Mg or Mn) for catalysis:
1 Grinter, R., Roszak, A. W., Cogdell, R. J., Milner, J. J. and Walker, D. (2012) The Crystal Structure of the Lipid II-degrading Bacteriocin Syringacin M Suggests Unexpected Evolutionary Relationships between Colicin M-like Bacteriocins. J. Biol. Chem. 287, 38876-38888 Best Regards, Rhys ________________________________________ From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] On Behalf Of Wei Liu [we...@me.com] Sent: 31 May 2013 11:25 To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] Calcium ions in enzymes Dear all, As we all know, many proteins contain calcium ions. Does anyone know if there are reported cases where calcium ions play a catalytic role rather than a structural role in enzymes? Best Wei Liu
