An easy example is heterotrimeric G-proteins. In the termination cycle, G-alpha bound to GTP will hydrolyze the GTP, which then allows it to associate again with the G-beta/G-gamma dimer.
Many membrane receptors (GPCRs, Chemotaxis, etc) can oligomerize and can be viewed like this, i.e., one dimer (protein dimer unit C) binds to another already associated dimer (units A and B). Also in DNA replication, transcription and mRNA splicing and translation complexes where recruitment of third or more protein occurs only after initial partners are already in complex. Thanks, Debanu. -----Original Message----- From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Davide Comoletti Sent: Friday, August 09, 2013 10:51 AM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] 3-way obligatory associating proteins Hi CCP4BB members, I was wondering if anyone knows of examples of 3-way obligatory associating complexes. In other words, instead of having protein A binding to protein B and protein B also binding to protein C, example of complexes where protein C binds ONLY when proteins A and B are already associated. Thanks for your help, Davide
