I know of at least one published example where seeding has been used to
crystallise a number of homologues:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243101/

(Sanchez-Weatherby 2006, Acta Cryst F 62:518)

There are probably others out there...

Certainly worth giving it a go.

Best wishes,

- Allister



On 27 December 2013 19:29, Mahesh Lingaraju <mxl1...@psu.edu> wrote:

> Dear all,
>
> I was wondering if it sounds logical to use the crystals from a possible
> structural homolog as seeds to induce nucleation ? (in terms of overall
> sequence, the proteins are considerably different but based on sequence
> alignment and structures from other related proteins, it is highly likely
> the protein would have the same structure.)
>
> Please comment if any of you had experience with this.
>
> Thank you
>
> Happy holidays :)
>
> Mahesh
>

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