Dear all, Does anyone happen to know examples of 2 ligands bind to a single protein / each monomer protein in 2 different ligand binding pockets? I know the following example: (1). phosphofructokinase, which binds ATP as both a ligand and a feedback inhibitor in different sites (2). 2 cAMP bound to each E. coli CAP monomer in the crystal structure.
Does any of you know other examples? Thank you so much! Best, Wei
