Hello All, I am appealing to the community as I don't seem to be able to find through Google what I am looking for, and I just don't have the ability to look through every structure in the PDB to find this. I have what I think is an interesting case: a two domain protein structure with a mostly hydrophobic interface between the two domains- the kicker is that I have two charged residues buried in this domain and they are identical. That is, I'm looking for an Arg-Arg or Asp-Asp type interaction (not Arg-Asp) where these residues are less than 4 Angstroms apart. So I was wondering if anyone had seen this in any other structure(s)? The really interesting bit is that this interaction actually regulates the activity of the enzyme domain although the domain interface isn't that close to the catalytic site.
Thanks in advance to all those who can find a reference to this kind of interaction. Cheers, tom
