A PhD position is available in my group, with deadline April 20th.
The fellowship (with good salary) is for a period of up to 4 years,and the starting date no later than 15.08.2014. For instructions on how to apply, please see: http://uio.easycruit.com/vacancy/1149353/64291?iso=no Job/ project description The PhD project will be in the field of structural biology on a project entitled "Shikimate pathway enzymes – Mechanism, function and drug discovery". The project consists of two parts, the first one aiming to answer fundamental mechanistic questions about enzyme catalysis, while the second part is concerned with functional investigations, directed evolution and drug design. Important methods to be applied are protein crystallography, molecular modeling, and quantitative binding studies. It is anticipated that the project will include a research stay at a foreign institution such as the ETH, Zurich, which is the base of our main international collaborators (Peter Kast and Don Hilvert). Since this project is clearly interdisciplinary, it will be suited for candidates from various disciplines, who are motivated to learn new skills. It is important that the candidate is qualified for experimental work in the laboratory, but also interested in theoretical questions. The candidate should further be confident working on her/his own, and in addition be a good team-player. The successful candidate will express and purify shikimate pathway enzymes and subject them to crystallization experiments. Candidates will be trained in computational structural chemistry by Michele Cascella (Department of Chemistry, University of Oslo) and use state-of-the-art computational techniques to investigate at the atomistic level the molecular mechanisms driving the enzymatic activity. Additional experience in organic synthesis would be beneficial. This work builds on previous research described in Sasso et al. 2009, EMBO J 28, 2128-2142 and Munack et al. 2012, Chem. Biodiversity 9, 2507-27. Our laboratories are state-of-the-art. The position will be associated to the National Norwegian PhD School in Structural Biology, BioStruct. Best, Ute -- -------------------------------------------------------------------------- Ute Krengel, PhD University of Oslo Department of Chemistry P.O.Box 1033 Blindern N-0315 Oslo, Norway Tel : +47 22 85 54 61 Fax : +47 22 85 54 41 e-mail : ute.kren...@kjemi.uio.no --------------------------------------------------------------------------
