Dear all, I'm sorry, this is a bit off-topic. I'm looking for a tool to compare pairs of binding sites. It doesn't need to be high-throughput, since I'll only be comparing ~100 pairs, but I'd like it to be robust and, more importantly, alignment-independent. Indeed, the binding sites I want to compare are not necessarily related in terms of amino-acid composition, but I'd like to still be able to detect similarities between them. Does anyone have suggestions? Thank you.
Sarah -- Sarah Barelier, Ph.D. Postdoctoral Researcher Shoichet Lab, UCSF sarah.barel...@blur.compbio.ucsf.edu Department of Pharmaceutical Chemistry 1700 4th Street, Byers Hall, Room N501 San Francisco, CA 94158-2550