Job Title Research
Associate Applications
are invited for a Research Associate position funded by the Medical Research
Council (MRC) for 3 years in the Centre for Biomolecular Sciences, Nottingham
University.
The
project title is: ADAMTS13 structure and
the molecular basis of VWF recognition and cleavage.
You
will join a well-established research group studying haemostatic proteins.
Specifically, the project will explore the structure and biochemistry of ADAMTS13.
ADAMTS13 is a multidomain plasma
metalloprotease that regulates von Willebrand factor (VWF) platelet-tethering
function through a single, highly specific proteolytic event. Deficiency in
ADAMTS13 or VWF causes thrombotic and bleeding disorders, respectively. The
activity and specificity of ADAMTS13 is manifest through the functional
dependency upon multiple exosite interactions with its substrate (VWF). How
these interactions are mediated and precisely what effect these have upon
ADAMTS13 structure, conformation and function is unclear. This project will aim
to probe the functionality of these ADAMTS13 exosites and key structural
features of ADAMTS13 through biochemical and crystallographic analyses.
There
are two postdoctoral posts associated with the grant, one is required to have
skills in protein crystallographic structure determination and analysis based
in Nottingham. The second post is based
at Imperial College using a wide range of techniques, ranging from recombinant
protein _expression_ (mammalian, insect and bacteria), protein purification,
protein biochemistry and enzyme kinetic analyses during the course of this
project.
We
are looking highly motivated candidates preferably with an interest in
haemostasis and a high standard of writing and presentation skills. You will
have a PhD as a requirement. Salary starting
salary up to £36,340 per annum Full-time, fixed-term available (3 years) from May 1st
2015 until April 30th 2018
Further
information about the research activity of the nottingham and imperial college
labs are
http://www.nottingham.ac.uk/research/groups/structural-biology/index.aspx http://www1.imperial.ac.uk/departmentofmedicine/divisions/experimentalmedicine/haematology/coag/
For
informal enquiries please contact: Dr Jonas Emsley jonas.ems...@nottingham.ac.uk ################################## Dr Jonas Emsley Professor of Macromolecular Crystallography, Division of Medicinal Chemistry & Structural Biology, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham. NG72RD Tel: +44 1158467092 Fax: +44 1158468002 email:jonas.ems...@nottingham.ac.uk http://www.nottingham.ac.uk/research/groups/structural-biology/index.aspx This message and any attachment are intended solely for the addressee and may contain confidential information. If you have received this message in error, please send it back to me, and immediately delete it. Please do not use, copy or disclose the information contained in this message or in any attachment. Any views or opinions expressed by the author of this email do not necessarily reflect the views of the University of Nottingham. This message has been checked for viruses but the contents of an attachment may still contain software viruses which could damage your computer system, you are advised to perform your own checks. Email communications with the University of Nottingham may be monitored as permitted by UK legislation. |
