Instead of Br which has a weak signal at its K edge, why not use Iodide at some wavelength (or energy) where it gives a stronger signal? The longer wavelength used will help with spot spatial resolution as well.
One may be fighting radiation damage, too. One may be fighting a moving (vibrating?) crystal, too. Sure, you already have some diffraction images, but a better experiment may make one's life easier. My advice would be to not use higher than a 200 mM (4% saturated) KI quick soak, but you didn't tell us how Br ended up in your crystals. Jim Recently, I got some datasets with weak anomalous Br signal. I tried to > merge them according to Q. Liu et al Science 336, p1033 (2012). I am using > the script multiscale@SSRL. The merged dataset has WEAKER anomalous > signals. > > Liu et al used SCALA for scaling and merging while multiscale@SSRL using > AIMLESS. Should this cause such a difference? The SCALA@SSRL has a > limitation on the number of frames it can process. So I cannot directly > check if this caused the difference. > > Any suggestions? >
