A DFG (German Research Foundation) funded Ph.D. position is available (starting immediately) at the Philipps-University of Marburg, Germany, to investigate the function of a mitochondrial ABC transporter, Atm1. The hitherto unidentified substrate exported by Atm1 is required for the assembly of Fe/S clusters in the cytosol and nucleus. Mutations in the atm1 gene have been shown to cause severe ‘mitochondrial Fe overload’ and are associated with the disease X-linked sideroblastic anaemia in humans.
We have recently elucidated the crystal structure of Atm1 that provides an excellent platform for further studies (Srinivasan V. et al., Science. 2014 Mar 7; 343(6175): 1137-40). Some of the most interesting and important aims are a) to elucidate the identity of the substrate and the mechanism of its export by Atm1, b) to establish the different conformational states involved in the transport mechanism, and c) to understand the relationship between mutation, biological structure and function and the disease state. To this end, the successful candidate will use a combination of powerful methods such as X-ray crystallography, cryo-electron microscopy and various techniques within biochemistry and cell biology. Applications are invited from talented graduates who hold or expect to gain a Masters degree or equivalent in chemistry, biochemistry, physics, biophysics or related disciplines. Previous experience in a structural biology related pursuit is desirable but not essential. Good English language skills are essential; knowledge of German would be helpful but is not required. The successful candidate will undertake a three-year Ph.D. studentship under the guidance of a team of structural and cell biologists. The student will have ample opportunities for data collection at ESRF, Grenoble, France, and the Swiss Light Source, Villigen, Switzerland. Applications and informal project enquiries should be sent to Dr. Vasundara Srinivasan (vasundara.sriniva...@staff.uni-marburg.de). Applications should include a CV, a letter of motivation detailing research interests and expertise, and contact details for at least two referees and should be sent by email as a single pdf file.
