Is anyone aware of a way to classify large numbers (100s) of conformationally-diverse crystal structures of a single protein (here calmodulin)? Pairwise RMSD matrixes seem possible, but may be complicated since there are two somewhat stable lobes, and the flexible linker in the middle. What I am imagining is a sort of multidimensional tree depicting the relationships in conformation space of the various structures.
I remember something for this called esct or similar, but can't seem to google it. Any thoughts? Jacob ******************************************* Jacob Pearson Keller, PhD Looger Lab/HHMI Janelia Research Campus 19700 Helix Dr, Ashburn, VA 20147 email: kell...@janelia.hhmi.org *******************************************
