Hello All, I am studying inhibitors for the NF-kB pathway and have come across an inhibitor- BAY-11-7821 which was originally designed as a IkB phosphorylation inhibitor. It has now ben reported that it also inhibits p65 ans p50 DNA-binding but I can't find an exact mechanism for it in the available literature.
Can anyone please help me understand this? Thanks and Regards. -- Charu Gupta Indian Institute of Technology Kanpur
