Critical Assessment of Techniques for Protein Structure Prediction (CASP)
community experiments aim to advance the state of the art in protein structure
modeling. Every other year since 1994, CASP collects information on soon-to-be
released experimental structures, passes on sequence data to the structure
modeling community, and collects blind predictions of structure for assessment.
About 100 modeling groups from around the world participate. Results of CASP
experiments are published in special issues of the journal PROTEINS (e.g.,
CASP12: Proteins Vol 86, Issue S1, March 2018).
The thirteenth CASP round is scheduled to start on May 1, 2018. The organizing
committee is particularly keen to include many cryo-EM-derived structure
targets in this round.
The success of CASP depends on the generosity of the structure determination
community. Modeling targets are needed over a wide range of difficulty, for
modeling both with and without the aid of templates. Targets that can be
modeled based on structural templates should ideally have 50% or less sequence
identity to the templates. Access to the structure in advance of its release by
the PDB or its publication is not needed. With sufficient notification to CASP
(a minimum of three weeks before release, more is better) there is no need to
delay structure release. If you have recently determined a novel protein
structure and will be depositing it to PDB, please suggest it as a target for
CASP by visiting www.predictioncenter.org/casp13/targets_submission.cgi. If you
have any questions please contact c...@predictioncenter.org.
CASP target providers are regularly invited to contribute to special issue
papers, for example:
2018: Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL,
Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding
CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW,
Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S,
Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ,
Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T.
(2018). Target highlights from the first post-PSI CASP experiment (CASP12,
May-August 2016). Proteins 86 (S1), 27-50. doi: 10.1002/prot.25392. PMID:
2896053
2016:
Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA,
Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J,
Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM,
Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T. (2016). Some of the
most interesting CASP11 targets through the eyes of their authors. Proteins 84
(S1), 34-50. doi: 10.1002/prot.24942. PMID: 26473983
2014: Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A,
Chen C, Cochran FV, Craig TK, Das R, Fass D, Garcia-Doval C, Herzberg O,
Lorimer D, Luecke H, Ma X, Nelson DC, van Raaij MJ, Rohwer F, Segall A,
Seguritan V, Zeth K, Schwede T. (2014). Challenging the state-of-the-art in
protein structure prediction: Highlights of experimental target structures for
the 10th critical assessment of techniques for protein structure prediction
experiment CASP10. Proteins 82 (S2), 26-42. doi: 10.1002/prot.24489. PMID:
2431898
2011: Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE,
Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt
JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K,
Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA,
Rousseau F, Tong L, Wernimont AK, Young J, Schwede T. (2011). Target highlights
in CASP9: Experimental target structures for the critical assessment of
techniques for protein structure prediction. Proteins 79 (S10), 6-20. doi:
10.1002/prot.23196. PMID: 2202078
Posted on behalf of the CASP organizing committee:
John Moult, University of Maryland, USA
Krzysztof Fidelis, University of California, Davis, USA
Andriy Kryshtafovych, University of California, Davis USA
Torsten Schwede, University of Basel, Switzerland
