Two post-doctoral positions in the Netherlands Cancer Institute Two post-doctoral positions are available in the Netherlands Cancer Institute in the group of Titia Sixma. We study mechanisms of enzyme regulation in DNA repair, using a combination of stuctural biology, biochemistry, biophysics and cellular assays. We are particularly focussed on processes of ubiquitin conjugation and DNA mismatch repair.
The institute is well set up for protein expression and characterisation (sharing equipment with the Protein Facility, an Instruct-ERIC and iNEXT participant), has an excellent computing infrastructure (hosting the NKI Research High Performance Computing Unit) and also regular, well-established access to testing and high resolution facilities for NMR, cryo-EM and synchrotrons. The labs and work discussions are shared with the groups of Tassos Perrakis and Robbie Joosten, who are interested in method development for structural biology (including the PDB-REDO project) as well as the group of Thijn Brummelkamp who is interested in developing and applying novel genetics approaches. The Netherlands Cancer Institute is a center of excellence with a high standard of biological research and an interactive atmosphere, with shared group meetings and social events. Amsterdam is a liveable city, with its many cultural amenities within easy reach and within easy access to most European cities, through the closeby Schiphol airport (<30 minutes). Currently we have vacancies for: 1) An experienced crystallographer for a project focussing on crystallization of allosteric enzymes. 2) A researcher with experience in cryo-EM for a project in DNA replication. Appointments are for 3 years. Applicants should write an e-mail with motivation, CV and names of three references to t.si...@nki.nl<mailto:t.si...@nki.nl> before May 19th. Titia Sixma Division of Biochemistry Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam
