Thanks to all who gave advice.  The reinstallation of XQuartz worked for me.  I 
was using the most updated version of XQuartz before I reinstalled it, but as 
Guillaume Gaullier told me:

“…macOS updates typically wipe out most files of your XQuartz installation 
(XQuartz.app will still be where it was originally installed, but unlike most 
Mac applications this one is not self-contained and has important files under 
/opt/X11 that get erased by a system update). And Coot requires XQuartz to 
display its window, so this is the most likely explanation for why it would not 
work after a system update.

Try reinstalling XQuartz from 
https://www.xquartz.org/<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.xquartz.org_&d=DwMFaQ&c=eRAMFD45gAfqt84VtBcfhQ&r=DO9lvOAiEYffd0DHXxXRFRhnm_KEyAdWVXbYX9zO5B8&m=zb3XqXe1iBKaPGEDyfZCe-uLxGJJVI0SzgY3of7iAxk&s=3FyzcByzIrl83gOdCoaiFSzE7Mbhtist6uxzCuQjIXA&e=>,
 then log out and log back in (or reboot, that should do it too), and see if 
Coot starts up normally.”

Happy solving,
Rachel

Rachel Werther / Research Technician III / Stoddard Lab / Basic Sciences / Fred 
Hutchinson Cancer Research Center / 
rwert...@fredhutch.org<mailto:rwert...@fredhutch.org> / 206-667-4066

From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of "Werther, Rachel 
A" <rwert...@fredhutch.org>
Reply-To: "Werther, Rachel A" <rwert...@fredhutch.org>
Date: Tuesday, October 15, 2019 at 5:01 PM
To: "CCP4BB@JISCMAIL.AC.UK" <CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp4bb] Issues in new Mac version 10.15

Hello All,

I downloaded the latest Mac Update, 10.15 Catalina, and then Coot wouldn’t open 
on my computer.

Phenix opened as usual.  I use the GUI, and the button that says “Open in COOT” 
was not greyed out, but would not launch the window.  When I tried to open it 
directly from Finder, it also failed to open.  The cartoon coot appeared on my 
recently opened section of my bottom-of-screen toolbar, but nothing happened.

Next I downloaded the latest CCP4-7.0.077, and followed the instructions to 
remove the extended attributes:
ATTENTION: If you are planning to install CCP4 from a tarball on Mac OS X 
version 10.13 or later (10.12 was not tested), you will have to remove extended 
attributes from the tar-gz-file before unpacking it, otherwise the app icons 
will not be functional (and you will be able to launch the CCP4 apps including 
ccp4i and ccp4i2 from the command line only). The extended attributes can be 
removed from the file _file_ using the command "xattr -c _file_". For example: 
xattr -c ccp4-7.0.065-macosx64.tar.gz

But when I try to open CCP4, I get this message:

Ccp4 cannot be opened because of a problem.

Check with the developer to make sure ccp4 works with this version of macOS. 
You may need to reinstall the application. Be sure to install any available 
updates for the application and macOS.

Click Report to see more detailed information and send a report to Apple.

And when I try to open Coot from the Finder, I again just see the icon in my 
recently opened section of my bottom-of-screen toolbar, but it doesn’t open.

Any advice?

Many thanks,
Rachel

Rachel Werther / Research Technician III / Stoddard Lab / Basic Sciences / Fred 
Hutchinson Cancer Research Center / 
rwert...@fredhutch.org<mailto:rwert...@fredhutch.org> / 206-667-4066

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