Dear all, I am looking to recruit two post-doctoral researchers experienced in cryo-EM, cryo-ET, or X-ray crystallography. The projects are focused on characterizing the replication of viruses in situ:
We study the infection of enteroviruses by a combination of FIBM and cryo-ET to determine the mechanism of enterovirus genome delivery into a host cell and changes in intra-cellular organization induced by infection. We complement the whole-cell studies by high-resolution cryo-EM of virus genome release under biologically relevant conditions in vitro. We employ cryo-ET and light microscopy to characterize the mechanisms that tailed phages, potential phage therapy agents, employ to invade a biofilm and infect bacteria. We use the cryo-ET to determine the functions of bacterial factors in phage genome delivery and characterize phage assembly. We employ time-lapse fluorescence microscopy to establish the relationship between the stage of biofilm development and its susceptibility to phage infection. Details about my research group can be found here: http://plevkalab.ceitec.cz <http://plevkalab.ceitec.cz/> Our in house cryo-EM facility: https://www.ceitec.eu/cryo-electron-microscopy-and-tomography-core-facility/cf94 <https://www.ceitec.eu/cryo-electron-microscopy-and-tomography-core-facility/cf94> Please get in touch with me if you have any questions. Pavel ################################ Pavel Plevka Laboratory of Structural Virology CEITEC, Masaryk University Kamenice 5 / A35 Brno, 625 00, Czech Republic Phone: +420 549 49 7756 ############################### ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
