Postdoctoral Researcher
Lawrence Berkeley Laboratory
Job ID: 89267
Division: Molecular Biophysics & Integrated Bioimaging (Computational 
Crystallography Initiative)
Date Opened: 12/23/2019

Summary:  Berkeley Lab’s Molecular Biophysics and Integrated Bioimaging 
Division has an opening for a Postdoctoral Researcher. In this role you will 
develop new computational methods for the structure determination and 
refinement of protein structures using the PHENIX software system. Primary 
duties and responsibilities will include development and implementation of 
numerical methods and new computational protocols, including the application of 
machine learning methods. The Phenix software is used worldwide for the 
determination of atomic structures using X-ray and neutron crystallography and 
cryo-electron microscopy. The software is developed as part of an international 
collaboration supported by the National Institutes of Health and the Phenix 
Industrial Consortium.

To apply visit - https://lbl.taleo.net/careersection/2/jobdetail.ftl?job=89267

Duties:

• Development and implementation of computational algorithms for structure 
determination using crystallography and cryo-electron microscopy including: 
improved methods for the optimization of models and automated detection of 
model heterogeneity.
• Application of machine learning methods to problems in crystallography and 
cryo-electron microscopy.
• Develop and test new components of the PHENIX software system in 
collaboration with others
• Document software developments.
• Collaborate with other researchers in the PHENIX program.
• Interact with P.I.s, other postdocs, scientists and external collaborators 
involved in the PHENIX project.
• Publication of research results in scientific journals and presentation of 
results at scientific meetings.

Additional Responsibilities as needed:

• Participate in workshop and tutorials to educate researchers in the use of 
Phenix
• Actively participate in writing progress reports

What is Required: 

• Ph.D. in computational crystallography, computational cryo-electron 
microscopy, computational biology, bioinformatics, computational chemistry or a 
related field
• Demonstrated experience in developing computational algorithms for solving 
problems
• Demonstrated experience with computational methods development
• Publications in macromolecular crystallography, cryo-electron microscopy or 
closely related fields
• Familiarity with Python, C++ and other software development tools
• Good programming and mathematical skills
• Strong interpersonal skills and the ability to work in a team environment 

Additional Desired Qualifications:

• Familiarity with macromolecular structure or computational chemistry.
• Experience with the practical aspects of crystallography and/or cryo-electron 
microscopy.

The posting shall remain open until the position is filled.

Notes: 

• This is a full time, 2 year postdoctoral appointment with the possibility of 
renewal based upon satisfactory job performance, continuing availability of 
funds and ongoing operational needs. You must have less than 3 years paid 
postdoctoral experience. Salary for Postdoctoral positions depends on years of 
experience post-degree.     
• Full-time, M-F, exempt (monthly paid) from overtime pay.
• This position is represented by a union for collective bargaining purposes.
• Salary will be predetermined based on postdoctoral step rates.
• This position may be subject to a background check. Any convictions will be 
evaluated to determine if they directly relate to the responsibilities and 
requirements of the position. Having a conviction history will not 
automatically disqualify an applicant from being considered for employment.
• Work will be primarily performed at: Lawrence Berkeley National Lab, 1 
Cyclotron Road, Berkeley, CA.

Learn About Berkeley Lab:

Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by 
advancing sustainable energy, protecting human health, creating new materials, 
and revealing the origin and fate of the universe. Founded in 1931, Berkeley 
Lab’s scientific expertise has been recognized with 13 Nobel prizes. The 
University of California manages Berkeley Lab for the U.S. Department of 
Energy’s Office of Science.

Working at Berkeley Lab has many rewards including a competitive compensation 
program, excellent health and welfare programs, a retirement program that is 
second to none, and outstanding development opportunities.  To view information 
about the many rewards that are offered at Berkeley Lab- Click Here.

Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative 
Action Employer. All qualified applicants will receive consideration for 
employment without regard to race, color, religion, sex, sexual orientation, 
gender identity, national origin, disability, age, or protected veteran status. 
Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination 
Provision under 41 CFR 60-1.4.  Click here to view the poster and supplement: 
"Equal Employment Opportunity is the Law.

--
Paul Adams
Division Director, Molecular Biophysics & Integrated Bioimaging, LBL 
(http://biosciences.lbl.gov/divisions/mbib)
Principal Investigator, Computational Crystallography Initiative, LBL 
(http://cci.lbl.gov)
Vice President for Technology, the Joint BioEnergy Institute 
(http://www.jbei.org)
Principal Investigator, ALS-ENABLE, Advanced Light Source 
(http://als-enable.lbl.gov)
Division Deputy for Biosciences, Advanced Light Source (https://als.lbl.gov)
Laboratory Research Manager, ENIGMA Science Focus Area (http://enigma.lbl.gov)
Adjunct Professor, Department of Bioengineering, U.C. Berkeley 
(http://bioeng.berkeley.edu)
Adjunct Professor, Comparative Biochemistry, U.C. Berkeley 
(http://compbiochem.berkeley.edu)

Building 33, Room 347
Building 978, Room 4126
Building 977, Room 180C
Tel: 1-510-486-4225
http://cci.lbl.gov/paul

Lawrence Berkeley Laboratory
1 Cyclotron Road
BLDG 33R0345
Berkeley, CA 94720, USA.

Executive Assistant: Ashley Dawn [ ashleyd...@lbl.gov ][ 1-510-486-5455 ]
--

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