Post-doctoral position in structural biology of host-pathogen interactions at IOCB Prague Job description An attractive, fellowship-funded post-doctoral position is open in Dr Sebastian Zoll’s group at the Institute of Organic Chemistry and Biochemsitry (IOCB) in Prague. Dr Zoll’s group is using a combination of biochemical, biophysical, immunological and structural biology techniques to understand the mechanisms of viral entry into mammalian cells. The successful candidate will be using cryo-EM to determine the structure of a viral capsid protein in complex with its cellular receptor and characterise the interaction using biophysical techniques. As part of this process the applicant will also generate monoclonal antibody and nanobody libraries as tools as well as for therapeutic applications.
Requirements - A recent PhD in structural biology or protein biochemistry/biophysics using at least one of the following techniques as the main method – cryo-EM, X-ray crystallography, small-angle X-ray scattering or NMR. - Strong computational skills. Experience with linux operating systems and command line interface is required. - Experience in expression construct design, protein purification and biophysical techniques to analyse protein-protein interactions (ITC, SPR etc.). - At least one first author publication in a high-quality, international, peer-reviewed journal The project is supported by a multidisciplinary network of international collaborators and provides excellent opportunities to receive additional training in foreign host institutions. The fellowship is granted for one year with possible extension by one more year. The earliest starting date is November 2020. The internal deadline for applications is 1 September 2020. For further information please see: https://www.uochb.cz/en/iocb-fellowships <https://www.uochb.cz/en/iocb-fellowships> The institute and the city IOCB Prague is the leading scientific research institution in the Czech Republic providing a dynamic, international environment that brings together researchers from various fields such as structural biology, molecular biology, medicinal and computational chemistry. Due to its long-standing history in applied science and strong ties with the pharmaceutical industry, IOCB enjoys an excellent funding situation and offers access to facilities for all modern structural and biophysical methods. The IOCB cryo-EM facility housing a 300 keV high-resolution and 200 keV screening cryo-electron microscope will become operational next year. In the meanwhile IOCB researchers enjoy privileged access to the EM facilities (screening microscopes and Titan Krios G3) at CEITEC. IOCB is situated near the city centre in a vibrating, historical quarter of Prague boasting beautiful architecture and a rich array of public amenities such as cafés, pubs, parks and grocery stores. Transport links by metro and tram are excellent with short distances to both airport as well as old town and Letna park with its stunning views over the Vltava river. How to apply? Please send a short motivation statement (max. 500 words), a full publication list and a copy of your CV to sebastian.z...@uochb.cas.cz <mailto:sebastian.z...@uochb.cas.cz> 2 letters of recommendation will be requested from short-listed candidates after the first round of application. Feel free to contact Sebastian for informal enquiries. Dr Sebastian Zoll Junior Group Leader Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Flemingovo namesti 542/2, 166 10 Prague 6 Czech Republic Phone: +420 220 183 591 Email: sebastian.z...@uochb.cas.cz <mailto:sebastian.z...@uochb.cas.cz> Facebook: https://www.facebook.com/IOCBP <https://www.facebook.com/IOCBP>rague ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
