Hello everyone, I do realize that this is not a NMR focused group, but I do hope that there are a few spectroscopists lurking around that could possibly answer a few questions (I am more of a modeler/computationalist):
The problem: I have two intrinsically disordered proteins that are known to interact (let's call them 1 and 2). I would like to get structural information (a conformational ensemble) for 1 and for the "complex" (1+2). Further down the line (depending on whether this is possible) I would also like to evaluate potential small molecule inhibitors for the said complex. Both 1 and 2 are <200 aminoacids long. The questions: 1. Could the cost of determining the "structure" for 1 and 1+2 be estimated? To be more precise, I am looking for a ball-park figure on how much a NMR measurement would cost in this case. 2. Could anyone recommend a good group/CRO that could provide such a service and not have an astronomical cost? 3. Any other suggestions/thoughts that you think might be worth mentioning (minimum quantity of protein necessary, purity, type of NMR etc) Many thanks for your help and time! Cheers! Sorin ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
