I think that SCALEIT should be able to do this. This was originally designed to 
compare Fs for Native and heavy atom derivate data, but can compare any two 
similar datasets (ie those that can sensibly be scaled together). You will need 
to merge the two mtz files first.

Cheers,

Andrew

> On 25 Jul 2022, at 20:52, Cygler, Miroslaw <miroslaw.cyg...@usask.ca> wrote:
> 
> Hi,
> I would like to calculate the R-merge for Fs from two datasets processed from 
> two different crystals. Tried to use Blend but got the message that Blend 
> requires R. Downloaded R but do not know how to tell CCP4 where it is located 
> on my Mac. Is there another program that would take two mtg files and merge 
> the Fs?
> Any help would be greatly appreciated. 
> 
> 
> Mirek
> 
> 
> 
> 
> 
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