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From: "charles w carter, jr" <cwcar...@ad.unc.edu<mailto:cwcar...@ad.unc.edu>> Subject: Re: [ccp4bb] Another folding AI Date: November 5, 2022 at 12:13:04 PM EDT To: "Nave, Colin (DLSLtd,RAL,LSCI)" <colin.n...@diamond.ac.uk<mailto:colin.n...@diamond.ac.uk>> As notable a scientist as Maxwell was, he also has been hailed as a creation scientist: https://creation.com/great-creation-scientists-james-clerk-maxwell AI approaches to folding are, I’ve found, remarkably accurate surrogates for all the many unsolved protein structures. I expect that quite solid research projects will eventually emerge that were not possible without the broadened database afforded by AF2. On Nov 5, 2022, at 11:58 AM, Nave, Colin (DLSLtd,RAL,LSCI) <000064fdcfc6624b-dmarc-requ...@jiscmail.ac.uk<mailto:000064fdcfc6624b-dmarc-requ...@jiscmail.ac.uk>> wrote: You don't often get email from 000064fdcfc6624b-dmarc-requ...@jiscmail.ac.uk<mailto:000064fdcfc6624b-dmarc-requ...@jiscmail.ac.uk>. Learn why this is important<https://aka.ms/LearnAboutSenderIdentification> There is another quote from an equally revered physicist – James Clark Maxwell “The actual science of logic is conversant at present only with things either certain, impossible, or entirely doubtful, none of which (fortunately) we have to reason on. Therefore the true logic for this world is the calculus of Probabilities, which takes account of the magnitude of the probability which is, or ought to be, in a reasonable man's mind.” I will leave people to decide for themselves which of these quotes is most relevant to the various AI approaches to protein folding, other than to say that at least one of them covers the uncertainty in any structure predictions. From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>> On Behalf Of Bryan Lepore Sent: 03 November 2022 12:22 To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: Re: [ccp4bb] Another folding AI [ emphasis/bold font is mine]: “In general we look for a new law by the following process. First we guess it. Then we compute the consequences of the guess to see what would be implied if this law that we guessed is right. Then we compare the result of the computation to nature, with experiment or experience, compare it directly with observation, to see if it works. If it disagrees with experiment it is wrong. In that simple statement is the key to science. It does not make any difference how beautiful your guess is. It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong. That is all there is to it.” -Richard Feynman The Character of Physical Law (1965) Chapter 7, “Seeking New Laws”, p.150 (Modern Library edition, 1994) ISBN 0-679-60127-9 ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
