Postdoctoral positions for the study of signaling complexes
The Peti Laboratory at the University of Connecticut Health Center has an immediate opening for two postdoctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and phosphatase drug/inhibitor development. All studies combine cryo-EM/NMR or X-ray crystallography with biochemical and in situ experiments, allowing postdocs to augment their training in those techniques that are new. Applicants with a strong background in biochemical techniques, and especially eukaryotic protein expression and protein crystallization or biomolecular NMR spectroscopy, are encouraged to apply. The Peti laboratory (recent publications see: https://pubmed.ncbi.nlm.nih.gov/?term=peti+w&sort=date&size=100) is housed in a newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell biology groups at UConn Health. The Peti laboratory is equipped with all necessary infrastructure to produce (E. coli, mammalian), purify and analyze protein and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam) as well as all needed equipment for cryo-EM sample preparation and data evaluation. UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR spectrometers). A new cryo-EM instrument will be installed in spring 2023 that will allow for rapid screening of auto-grid/clipped samples of sample conditions. Access to Krios instruments for data collection is readily available. UCHC has a welcoming, collaborative and vibrant environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min). Starting date, salary and project details are negotiable. Please e-mail a Cover Letter and CV to Wolfgang Peti (p...@uchc.edu) ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
