*Postdoctoral Position: Structural biology of the actin cytoskeleton*
Djinovic lab isinterested in the molecular mechanisms underlying the
architecture and assembly of the actin based cytoskeleton. Thisproject
focuses on ubiquitous human proteins α-actinin-1 and -4, which
self-associate to form a homo- and hetero dimeric units that cross-link
actin filaments in calcium-regulated manner. The projectis jointly
funded by Austrian and Slovene Science Funds and is a close
collaboration between Djinovic group at Vienna, Austria, and Pavsic
group at University of Ljubljana, Slovenia. The two young and dynamic
groups will join forces to understand the detailed molecular mechanism
of regulation of this essential F-actin crosslinking protein by calcium
and specific phosphoprylation events.
We employ an integrated approach by combining biochemistry, cell,
chemical and structural biology approaches, including X-ray
crystallography, small angle scattering and (starting) cryo-EM. The
successful candidates will be involved in all aspects of the project,
including protein expression, purification, biophysical, biochemical
characterization and integrative structural biology.
*Qualifications and experience: *The applicants should hold a PhD degree
in a relevant field and two years of post-doctoral experience in a
structural biology lab. Strong background in molecular cloning,
expression, and purification of protein complexes is essential. Prior
knowledge of crystallography and/or single-particle electron microscopy
is needed. Excellent spoken and written English are required.
The successful applicants will work in a stimulating scientific
environment: Department for Structural and Computational Biology
<https://structbio.univie.ac.at/>at Max Perutz Labs
<https://www.maxperutzlabs.ac.at/>, a joint venture between University
of Vienna and Medical University of Vienna. The Labs are located at
Vienna BioCenter <https://www.viennabiocenter.org/>, the largest
molecular life science hub in Austria. We are equipped equipped with
/state-of-the-art/ research infrastructure
<https://structbio.univie.ac.at/research-infrastructure-facilities/>for
experimental and computational work, and have access to facilities at
Vienna Biocenter Core Facilities
<https://www.viennabiocenter.org/facilities/>, which includes
mass-spectrometry, a blend of Protein technologies and electron
microscopy instruments (Glacios, Krios). The group has in addition
access to cryo-EM Titan-Krios through BAG at ESRF and to major European
synchrotron high-brilliance X-ray sources.
1.A concise description of research experience, including a list of
published peer-reviewed articles.
2.Copyof the PhD diploma (or equivalent).
3.Contact details for *three references*, of which one should be your
PhD supervisor.
Please preparethe applicationas a*single package in PDF format*, and
send it to <*admin.v...@univie.ac.at* <mailto:admin.v...@univie.ac.at>>,
subject Postdoctoral position in Djinovic Lab.
Further information can be obtained from Kristina Djinovic
carugokristina.djino...@univie.ac.at
<mailto:kristina.djino...@univie.ac.at>.
*Closing date:*review of applications begins immediately and will
continue until the position is filled.
*WEB-PAGES*
https://www.maxperutzlabs.ac.at/research/research-groups/djinovic
https://www.maxperutzlabs.ac.at/
https://structbio.univie.ac.at/
https://structbio.univie.ac.at/research-infrastructure-facilities/
https://www.viennabiocenter.org/
https://www.viennabiocenter.org/facilities/
--
Department of Structural and Computational Biology
Max Perutz Labs
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria
e-mail:kristina.djino...@univie.ac.at
Phone: +43-1-4277-52203
Phone: +43-1-4277-52201 (secretary)
Mobile A: +43-664-817 5259
Fax: +43-1-4277-9522
--
Department of Structural and Computational Biology
Max Perutz Labs
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria
e-mail:kristina.djino...@univie.ac.at
Phone: +43-1-4277-52203
Phone: +43-1-4277-52201 (secretary)
Mobile A: +43-664-817 5259
Fax: +43-1-4277-9522
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