Dear CCP4 Community, My lab at Stanford (https://rogala.stanford.edu) is thrilled to announce a newly funded position for a postdoctoral scholar with a background in structural biology or protein biochemistry. Expertise in working with either integral or peripheral membrane proteins will be an advantage, but it is not a requirement. Compensation of our postdocs is set to the Stanford rates <https://postdocs.stanford.edu/funding-rates-and-guidelines>.
Our lab is relatively new, and we are in search of driven candidates with a start-up mentality and a deep interest in deciphering protein mechanisms. Please share this opportunity with your soon-to-graduate PhD students who may be looking for their next career step! We have a flexible start date, so if you anticipate that your PhD might take another year to complete but you like our research, we encourage you to apply. Please see the official ad on the Stanford postdoc website here <https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-kacper-rogala>, and a short blurb below — describing what our lab is about. Potential candidates, please write a few lines about yourself — about your previous research experience, and what you liked about our lab that got you interested! Please include your CV and contact details to three references. Many thanks and best wishes, Kacper KACPER ROGALA, D.PHIL. *Assistant Professor* *–––––––––––––––––––––––––––––––-* Department of Structural Biology <https://med.stanford.edu/structuralbio.html> Department of Chemical and Systems Biology <https://chemsysbio.stanford.edu/> Stanford Cancer Institute <http://med.stanford.edu/cancer.html> Stanford University School of Medicine Biomedical Innovations Building 240 Pasteur Drive, 4700 | Palo Alto, CA, 94304 https://rogala.stanford.edu We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as growth factors, to determine cellular decisions, especially the decision: to grow or not to grow? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms. We primarily work on proteins that associate with biological membranes — either as large peripheral membrane complexes, or as integral membrane transporters. Our latest papers on this topic are: - (REVIEW) Linde-Garelli and Rogala (2023) Structural mechanisms of the mTOR pathway. Current Opinion in Structural Biology. 82:102663. PMID: 37572585 <https://pubmed.ncbi.nlm.nih.gov/37572585/>. - Valenstein and Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610-616. PMID: 35831510 <https://pubmed.ncbi.nlm.nih.gov/35831510/>. - Rogala et al. (2019) Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366(6464):468-475. PMID: 31601708 <https://pubmed.ncbi.nlm.nih.gov/31601708>. - Shen and Rogala et al. (2019) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. Cell, 179(6):1319-1329.e8. PMID: 31704029 <https://pubmed.ncbi.nlm.nih.gov/31704029>. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
