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Amir Khan Trinity College Dublin Wednesday, September 20, 2023, 13:30 EDT Structural biology of phospho-dependent signaling in the context of LRRK2 kinase and Parkinson’s disease https://bnl.zoomgov.com/meeting/register/vJIsfu6vqzkvHaKAt9fDIW--AHKPN8yemIw Abstract Activation of LRRK2 kinase activity has long been associated with inherited and sporadic forms of Parkinson’s disease. However, the molecular basis for the defects in subsequent cell signaling that lead to neuronal cell death remain unknown. LRRK2 phosphorylates numerous Rab small GTPases and takes control of their functions in the regulation of vesicular and membrane trafficking. Here I will discuss how LRRK2 affects downstream cell signaling complexes using biophysical and structural techniques. These studies contribute to our understanding of how LRRK2-mediated phopshorylation is linked to neurodegeneration in the context of Parkinson’s disease. =============================================================================== Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e nsls.lifescien...@gmail.com<mailto:nsls.lifescien...@gmail.com> w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 Supporting Grants: CBMS is supported by NIH-NIGMS #P30GM133893, and by the DOE-BER #KP1605010. Any work performed at NSLS-II is supported by DOE-BES under contract # DE-SC0012704. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
