Dear colleagues, Our team “Nuclear receptors as integrators of endogenous and environmental signals” (https://www.cbs.cnrs.fr/index.php/en/home-equipea5) has an opening for a 2-year postdoctoral research fellow funded by the French National Research Agency.
Project A number of compounds present in the environment act as endocrine disruptors and cause adverse effects in humans and wild-life by interfering with the normal signaling of various cellular targets. Mounting data suggest a link between the increasing exposure to these chemicals and the development of diseases including reproduction defects, hormone-related cancers, or metabolic disorders. Our team is using a battery of structural, biophysical and cell-based approaches to provide a rational framework for better understanding and combating the impact of environmental pollutants on human health. The position requires the applicant to work on structural and biochemical characterization of various receptors including the peroxisome proliferator activated receptor γ (PPARγ), the pregnane X receptor (PXR) and the aryl hydrocarbon receptor (AHR). Qualifications Applicants must hold a PhD in biological sciences (preferably in biochemistry or structural biology), and should have a strong background in protein expression and purification, cryogenic electron microscopy and/or X-ray crystallography. Anticipated starting date: 1st of September 2024 Application The application, including CV, motivation letter and 2 reference letters, should be sent to William Bourguet (william.bourg...@cbs.cnrs.fr) Recent publications of the team in the field: - Kwong HS, et al. Structural insights into the activation of human Aryl Hydrocarbon Receptor by the environmental contaminant benzo[a]pyrene and structurally related compounds. J Mol Biol. 2023 Dec 20:168411. - Gruszczyk J, et al. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nat Commun. 2022 Nov 16;13(1):7010. - Delfosse V, et al. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2020551118. Best wishes. --- William Bourguet Nuclear receptors as integrators of endogenous and environmental signals Center for Structural Biology CNRS UMR5048 / INSERM U1054 / UM 29 rue de Navacelles 34090 Montpellier, France Phone: 33 4 67 41 7702 Fax: 33 4 67 41 7913 http://www.cbs.cnrs.fr/index.php/en/home-equipea5 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
