PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.


Our research focuses on the structural biology of G protein-coupled receptors 
involved in neurobiology and immunology, using single particle cryoEM, 
complemented with biophysical assays.


USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis


Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
protein purification and experience with cryoEM data analysis is a plus. A 
successful candidate is expected to be highly skilled and self-motivated and is 
willing to work in a collaborative environment. The Postdoctoral salary depends 
on qualifications and relevant experiences according to USC standards.


Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu<http://usc.edu/>. Please attach a cover letter, Curriculum 
Vitae, research statement, publication list and a reference letter. There is no 
deadline for this posting and applications will be evaluated on a rolling basis.


Current group website: https://dornsife.usc.edu/gati/



Recent work from our group includes:


Molecular basis of anaphylatoxin binding, activation, and signaling bias at 
complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, 
Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, 
Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)


Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. 
Nature. 606 (2022) 820-826


Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, 
Gati C*, Cherezov V*. Nature. 584 (2020) 298-303


A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, 
Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412

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