Hello,

I don’t know if crystallographic software is commonly GPU-accelerated. Most 
software we use to process cryoEM data is and requires CUDA, which only works 
on Nvidia hardware with their driver. Also seems to be the case for a lot of 
deep learning software. Like it or not, it’s simply a fact. So if you use such 
software, then one important criterion to help narrow down the list from 
distrowatch is to pick a distribution that Nvidia officially supports with 
their driver.

See here for supported distributions: 
https://developer.nvidia.com/cuda-downloads?target_os=Linux&target_arch=x86_64
This leaves the usual suspects as compatible options, with the notable 
exception of Alma Linux. So, if you hesitate between Alma and Rocky, having an 
Nvidia GPU and software using CUDA is a situation in favor of Rocky.
A recent nice development is that Nvidia now offers an open-source version of 
their driver. I have been using it on Rocky 9 and it works smoothly (and I was 
surprised it took so little time between the announcement and the actually 
usable release).

As Tim suggested, Debian would also be a fine option, with a supported Nvidia 
driver. It would be a bit less familiar than Rocky for someone coming from 
Scientific Linux. The smooth upgrade between major versions is a good reason to 
choose Debian (among other good reasons). As far as I know, Rocky doesn’t let 
you upgrade to the next major version, but with an adequate partition scheme 
you can do a "clean" installation without touching the home directories for the 
same result (it is just a bit more work than one command, and more critical to 
back up the home directories beforehand).
Regarding the heartbleed vulnerability, some versions of Debian were affected, 
but a fix was released promptly: 
https://lists.debian.org/debian-security-announce/2014/msg00071.html
CentOS as well: 
https://lists.centos.org/pipermail/centos-announce/2014-April/020248.html
Rocky and Alma didn’t exist back then.

I hope this helps,

Guillaume


On 26 Apr 2024, at 19:18, Jonathan Clinger 
<clinge...@gmail.com<mailto:clinge...@gmail.com>> wrote:

If you want to keep as close to scientific linux as possible, I would suggest 
Alma or Rocky Linux. Those were the two options my group considered when the 
writing was on the wall for scientific linux and we were ramping up our 
workstations. We ended up going with Alma, but I'm not sure it is any better 
than Rocky. We'll have to wait and see how much they diverge over time.

If you are ok with moving to something more different, Ubuntu or one of its 
derivations would probably do just fine.

Cheers! -Jonathan Clinger

On Fri, Apr 26, 2024 at 9:58 AM Jon Cooper 
<0000488a26d62010-dmarc-requ...@jiscmail.ac.uk<mailto:0000488a26d62010-dmarc-requ...@jiscmail.ac.uk>>
 wrote:
Hello Harry

Any of the top 50 on distrowatch.com<http://distrowatch.com/> will basically be 
fine and the next 20 or so on the list will probably be fine. Then you start 
getting into the twilight zone. I am sure that will help greatly to narrow down 
your choice ;-0

Best wishes, Jon Cooper. 
jon.b.coo...@protonmail.com<mailto:jon.b.coo...@protonmail.com>

Sent from Proton Mail mobile



-------- Original Message --------
On 26 Apr 2024, 16:46, Harry Powell < 
0000193323b1e616-dmarc-requ...@jiscmail.ac.uk<mailto:0000193323b1e616-dmarc-requ...@jiscmail.ac.uk>>
 wrote:

Hi folks For many years I’ve been using Scientific Linux as my OS of choice 
(when not using my Mac) - but it’s been discontinued. SL was based on RHEL, and 
had useful things like a less-buggy Fortran/C/C++ compiler than that released 
by RH. What do people here recommend as a replacement? Harry 
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