Please do not reply directly to this message CCP4 collaboratively develops and supports cutting edge methods for the experimental determination and analysis of protein structure, principally by X-ray crystallography. New developments are released through the CCP4 suite of programs, which includes software from a diverse group of scientists from a network of cooperating centres. This network includes partners from Diamond Light Source, the Research Complex at Harwell, the LMB / MRC Cambridge, and the Universities of Liverpool, Newcastle and York. All partners recognise the importance of allowing flexible home/office working where possible.
Within this framework, several postdoctoral research assistant positions are available at participating institutions: Diamond post A 3.5 year PDRA position is available at Diamond Light Source, Harwell Campus. We seek to recruit an experienced data analysis scientist with knowledge of statistical analysis methods. The successful candidate will build on recent exciting results in the field of time resolved serial crystallography at Diamond and other facilities. The successful candidate will develop new approaches to analyse X-ray diffraction data from macromolecular crystallography experiments aiming to be able to robustly identify when changes in the data are significant and correspond to relevant changes in macromolecular structure. Embedded within the data analysis and macromolecular crystallography groups the successful candidate will have a background in statistical analysis and the development of software tools. https://vacancies.diamond.ac.uk/vacancy/pdra-in-statistical-analysis-of-change-in-diffraction-data-559648.html For informal enquiries contact Dr Graeme Winter [he/him] (graeme.win...@diamond.ac.uk<mailto:graeme.win...@diamond.ac.uk> ) or Prof. Mike Hough [he/him] (michael.ho...@diamond.ac.uk<mailto:michael.ho...@diamond.ac.uk>). LMB post A 3-year PDRA position is available at LMB to work for the development of computational methods and software for modelling, refinement and validation of atomic structure models using multiple data sources including crystallographic and single particle cryoEM data. Building, refinement, and validation of consensus as well as models of differences will require good knowledge of structural biology as well as computational methods. One of the applications of the developed methods will be to time-resolved crystallography where identification of time dependent changes of molecules is the main aim of experiments. The candidate should have experience in computational structural biology software development and good knowledge of python and c++ is essential. For informal enquiries contact Dr Garib Murshudov [he/him] (ga...@mrc-lmb.cam.ac.uk<mailto:ga...@mrc-lmb.cam.ac.uk>) Liverpool post A position is available to develop software for structure validation using Deep Learning-derived predicted residue contacts and distances, and for optimal Molecular Replacement using the results of the latest RNA structure prediction methods. The candidate should have a detailed understanding of macromolecular structure, software development skills, ideally in Python, and familiarity with the use and results of current Deep Learning-based structure prediction methods such as AlphaFold. An understanding of the principles of X-ray crystallography and experience in Machine Learning are desirable. https://tinyurl.com/yhay4xtb For informal enquiries contact Prof. Dan Rigden [he/him] (drig...@liverpool.ac.uk<mailto:drig...@liverpool.ac.uk>) Prof Daniel Rigden (He/Him) Department of Biochemistry, Cell and Systems Biology Institute of Systems, Molecular and Integrative Biology Room 101, Biosciences Building University of Liverpool Crown St., Liverpool, L69 7ZB (+44) 151 795 4467 www.liverpool.ac.uk/systems-molecular-and-integrative-biology/staff/daniel-rigden/<http://www.liverpool.ac.uk/systems-molecular-and-integrative-biology/staff/daniel-rigden/> Scholar Google<https://scholar.google.co.uk/citations?user=8l7rbMIAAAAJ&hl=en> @DanielRigden<https://twitter.com/DanielRigden> [cid:2d246867-f8dc-4a3b-86ce-66f419b55949] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
