On Tuesday, *March 25th*, 2025 at noon (Eastern), *Eva Nogales* will present "*Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery*" in the next session of the webinar series *Advancing Drug Discovery *from the National Academies of Sciences, Engineering and Medicine. Recordings of prior talks in the series are also available from NAS <https://www.nationalacademies.org/our-work/advancing-drug-discovery-a-webinar-series-of-the-national-academies-of-sciences-engineering-and-medicine>.
---------- Forwarded message --------- From: NASEM Advancing Drug Discovery Webinar Series < [email protected]> Date: Thu, Mar 13, 2025 at 2:17 PM Subject: Tuesday 3/25 Drug Discovery Webinar: Unique Capabilities of Cryo-EM in Structure Determination Join Dr. Eva Nogales, Distinguished Professor in Molecular and Cell Biology at the University of California, Berkeley. [image: National Academies of Sciences, Engineering, and Medicine] ADVANCING DRUG DISCOVERY WEBINAR SERIES Tuesday, March 25th — 12 pm - 1 pm (ET) <https://nationalacademies.us4.list-manage.com/track/click?u=5dc4a6f3f17fd11adf3be4912&id=ea29c4cd88&e=66fc8619b0> Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery As part of Advancing Drug Discovery: A Webinar Series of the National Academies of Sciences, Engineering and Medicine <https://www.nationalacademies.org/our-work/advancing-drug-discovery-a-webinar-series-of-the-national-academies-of-sciences-engineering-and-medicine>, a session on *Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery *will be held on Tuesday, March 25th, 2025 at noon (EDT). The 60-minute session will consist of a presentation from *Dr. Eva Nogales*, Distinguished Professor in Molecular and Cell Biology at the University of California, Berkeley, with time for a short question and answer session at the end. *Abstract:* Cryo-EM has emerged as a powerful structural technique that is generally applicable to samples spanning from single proteins to large viruses, including integral membrane proteins and large macromolecular assemblies, even when they are flexible or involve transient, regulatory interactions. The minimal requirement concerning sample amount and the capacity to describe conformational ensembles make cryo-EM the technique of choice when characterizing samples that challenge methods like NMR or crystallography. The resolution of the structures obtained by cryo-EM has been increasing with improvement in hardware and software, making it relevant in the drug discovery arena. Dr. Nogales will introduce the technique and demonstrate its capability in studies of the microtubule cytoskeleton, molecular machinery involved in gene expression regulation, and other biological systems that had defied structural characterization by more traditional methods. *Register to join us live on Tuesday, March 25th or register to receive an email update when the recording and slides become available. * REGISTER NOW <https://events.nationalacademies.org/44669_03-2025_unique-capabilities-of-cryo-em-in-structure-determination-and-its-potential-in-drug> *Eva Nogales* is a Distinguished Professor in Molecular and Cell Biology at the University of California, Berkeley. She studied physics at the Universidad Autónoma de Madrid, did her doctorate in biophysics at the University of Keele, UK, and carried out her postdoctoral work at the Lawrence Berkeley National Laboratory (LBNL) where she obtained the structure of tubulin using electron crystallography. She joined the University of California, Berkeley in 1998 and has been a Howard Hughes Medical Institute Investigator since 2000. She is also a Senior Faculty Scientist at LBNL. Nogales is an elected member of the National Academy of Sciences of the USA and the American Academy of Arts & Sciences, and foreign member the Real Academia de Ciencias de España and of EMBO. In 2020 she served as President of ASCB. In 2023 she received the Shaw Prize in Life Science and Medicine. Her lab uses cryo-EM to describe the structure, dynamics and interactions of large biological assemblies essential to the life of all eukaryotic cells, including microtubules and transcription and epigenetic complexes. *A collaboration between the U.S. National Committees on: Crystallography, Chemistry, CODATA & the Board on Chemical Sciences and Technology* This webinar series is sponsored by Thermo-Fisher, Abbvie, Schrödinger, and Oak Ridge National Laboratory FOLLOW US [image: Facebook] <https://www.facebook.com/NationalAcademies/> [image: Twitter] <https://x.com/theNASEM> [image: LinkedIn] <https://www.linkedin.com/company/the-national-academies> *Copyright © 2025 National Academy of Sciences, All rights reserved.* You are receiving this message because you requested to be sent emails from Policy and Global Affairs at the National Academies. *Our mailing address is:* National Academy of Sciences 500 5th St NW Washington, DC 20001-2736 Add us to your address book Want to change how you receive these emails? 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