Dear all!
You can find a lecture text: 
The hydrophobic effect: is water afraid, or just not that
interested? 
by Todd P. Silverstein

ChemTexts (2020) 6:26
https://doi.org/10.1007/s40828-020-00117-8 

Best,
Winfried Hinrichs

----------------------------------------------------------------------
Dr. rer. nat. Winfried Hinrichs
Professor and Chair of Biochemistry, Emeritus

University of Greifswald
Institute for Biochemistry
Felix-Hausdorff-Str. 4
D-17487 Greifswald, Germany

E-mail [email protected]

http://orcid.org/0000-0002-0435-4565

mobile phone +49 17654172520

Private address
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22339 Hamburg, Germany
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Am Donnerstag, den 14-08-2025 um 07:33 schrieb Natesh Ramanathan:




Dear All,
            I have read in old  books and taught by
able teacher while I was a student that :
1. The most important non covalent interaction for protein stability
is Van der Waals interaction.
2. The  most important non covalent interaction for protein folding
is hydrophobic interaction.
          Does anyone recollect which book mentions this.. or any
reference to the papers would be really helpful?
While the points  1. and 2. may deviate for specific cases.. in
general for most cases, these were valid, from my knowledge.

Today.. Google says no.... for both these points 1 and 2...
For both google says the most important ones are : hydrogen bond,
hydrophobic interactions a and  ionic interactions...

Is it time to calibrate our old knowledge or disregard what
google/AI says?

Many thanks for your input.. 
You can send me a private reply if you wish not to spam others INBOX.


Need to set this right.. as it was bothering me and I need to
teach  with the right knowledge.

Many thanks... 
Best regards,
Natesh-- 







----------------------------------------------------------
"Live Simply and do Serious Things .. "
- Dorothy Mary Crowfoot Hodgkin OM, FRS

"In Science truth always wins"
- Max Ferdinand Perutz OM FRS
----------------------------------------------------------
Dr. Ramanathan Natesh
Associate Professor, 
School of Biology and Center for High-Performance Computing (CHPC),
Founding and Current President of Cryo Electron Microscopy and 3
Dimensional Image Processing Society of India (CEM3DIPSI),
Indian Institute of Science Education and Research Thiruvananthapuram
(IISER-TVM),

Maruthamala P.O., Vithura,
Thiruvananthapuram,  695551, Kerala, India

[email protected]
http://faculty.iisertvm.ac.in/natesh

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