The Gati Lab at the University of Southern California (USC) is seeking highly motivated postdoctoral researchers or research technicians to join our interdisciplinary research program focused on G protein-coupled receptor (GPCR) biology and pharmacology.
Our research aims to elucidate the structural and mechanistic principles governing GPCR signaling and to translate these insights toward novel therapeutic strategies. We integrate cutting-edge cryo-EM with cell-based pharmacological assays and computational modeling to study GPCRs activated by diverse ligands, including neurotransmitters, peptides, and immune modulators. Recent work from our lab includes a variety of cutting-edge studies on GPCR structural pharmacology, including: the first structures of Class C intermediate states - GABA-B (Shaye et al. 2020, Nature, PMID: 32555460), the first structure of an inactive GPCR-BRIL fusion - Fzd5 (Tsutsumi et al. 2020, eLife, PMID: 32762848), the first structures of inverse agonist-bound GPCR-G protein complexes - KOR (Tyson et al. 2025, Nature Chemical Biology, PMID: 39775170), the first structures of GDP-bound intermediate states of GPCR-G protein complexes, elucidating the activation mechanism and pharmacology of MOR (Khan et al. 2025, Nature, PMID: 41193810). A more comprehensive list of publications can be found on our website: www.gati-lab.com <http://www.gati-lab.com/> The lab is expanding its efforts toward single molecule biophysics and structure-guided drug discovery, leveraging collaborations in computational biology, chemical biology and protein engineering. If you are passionate about GPCR biology, structural biology, pharmacology, and modern drug discovery, we encourage you to apply. 𝐃𝐞𝐬𝐢𝐫𝐞𝐝 𝐄𝐱𝐩𝐞𝐫𝐭𝐢𝐬𝐞 We welcome applicants with experience in two or more of the following areas: 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲: Recombinant protein expression in Sf9 and mammalian expression system. Purification of membrane proteins. 𝐂𝐫𝐲𝐨-𝐄𝐌: Single-particle cryo-EM analysis of membrane proteins, including GPCR complexes. 𝐆𝐏𝐂𝐑 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐨𝐥𝐨𝐠𝐲: Cell-based signaling assays (e.g., BRET-based assays), receptor trafficking studies, or advanced imaging approaches. 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐁𝐢𝐨𝐥𝐨𝐠𝐲: Molecular dynamics (MD) simulations, structure-based drug design, or protein/antibody engineering. 𝐐𝐮𝐚𝐥𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 Applicants must hold a PhD or BSc in a relevant discipline (e.g., structural biology, biochemistry, pharmacology, computational biology, or related fields) and demonstrate strong written and verbal communication skills. Interested candidates should apply directly to Prof. Gati (gati[at]usc.edu <http://usc.edu/>) and include a CV, a brief statement of research interests, and contact information for two academic references. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
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