Just a quick thought: If, for example, you are building reusable, singleton components (sorry for the OO buzzwords, but it is descriptive terminology), then you can load those CFCs into Application scope and have them exist in memory only once but still be used across all requests in the app. An include, by contrast, has to be rendered anew each time the outer template is called. In other words, using components makes it easier to encapsulate functionality, but there is otherwise little *functional* difference.
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