Some related tickets:

Server load (open) - https://dev.clojure.org/jira/browse/CLJ-1891

Spec load (closed but some more info) - 
https://dev.clojure.org/jira/browse/CLJ-2108

refer perf (open) - https://dev.clojure.org/jira/browse/CLJ-1730

However, all of these are really just some easy one- time wins (can shave about 
0.2 s maybe) and don’t give you any qualitatively different experience. 

For that something more is needed. If you are aot compiling, then aot+direct 
linking+lazy vars (patch is on the page you linked as an attachment) work 
together to load and run significantly less bytecode. If not aot, then the 
additional costs are primarily in reading and compiling (about 50/50) iirc. 
It’s unclear how to make those substantially faster.

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