In https://github.com/jaycfields/jry I define update values, which allows you 
to 
(update-values {:a 1 :b 2} inc) ;=> {:a 2 :b 3}

I've used that in combination with update-in to do all sorts of 
transformations. 
That is obviously designed for maps, which is what your example looks like to 
me. (I don't know Mathematica)

Sent from my iPad

On Jul 17, 2012, at 9:17 PM, Seth Chandler <[email protected]> wrote:

> I'm new both to Clojure and to this group, so please be gentle.  I come to 
> Clojure mostly from a Mathematica background, which has a certain Lispyness 
> to it.  One of the things one can do in Mathematica is to map a function to 
> an s-expression but not at its top level, but rather at some user specified 
> level.  Thus Map[f, {{a,b},{c,d}},{2}] will (because of the {2} as the last 
> argument) evaluate to {{f[a],f[b]},{f[c],f[d]}} rather than 
> {f[{a,b}],f[{c,d}]}.  I have found this capability of having functions that 
> work at levels of an expression to be extremely valuable.  Is there work 
> already done that extends the higher order functions to permit something like 
> this.  And, yes, I am sure one could write a macro and perhaps that has 
> already been done, but I was curious as to what was out there.  My Google 
> search did not yield much on this topic, but perhaps I used the wrong Clojure 
> vocabulary.
> 
> Thanks
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