*apply *is slow. However you can increase performance by 60% with the 
following macro, if you have a fixed length in S.

(defmacro *applyn *[n f & s]
    (loop [curr `(list* ~@s), n n, vars[] vals[]]
        (if(pos? n)
           (let[v(gensym)]
                (recur v (dec n) (conj(conj vars v) (if (seq vars) (list 
'next curr) curr))
                           (conj vals(list 'first v))))
          `(let[~@vars] ~(cons f (seq vals))))))

(let[t(fn[](*apply       *+ '(1 2 3 4 5 6 7 8 9 10)))] (time(dotimes [_ 
1000000] (t)))) ; ~680 msec
(let[t(fn[](*applyn *10 + '(1 2 3 4 5 6 7 8 9 10)))] (time(dotimes [_ 
1000000] (t)))) ; ~220 msec

So, if you have inner loops, that must be optimized for performance, you 
might remember this possibility. Even other functions could be optimized 
this way. However, "*premature optimization* is the root of all evil". 
Beside, the generated code is more space consuming.

*Marc*

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