s7 doesn't know how to communicate with slime (or geiser), and it's not Common Lisp, so loading quicklisp code, or running sbcl has no effect. Snd can communicate with emacs through s7, forth, or ruby, and inf-snd.el has instructions. I use the built-in repls (and a separate emacs); in that case you load a file with (load "a-file.scm"), and evaluate s7 code by typing it at the prompt, just as in any other repl.
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